- 혈당 강하제 metformin 중독 후 발생한 심각한 산혈증 1례
- Severe Acidosis after Massive Metformin Overdose
- ㆍ 저자명
- 김보인,정진희,어은경,Kim. Bo-In,Jung. Jin-Hee,Eo. Eun-Kyung
- ㆍ 간행물명
- 대한임상독성학회지
- ㆍ 권/호정보
- 2008년|6권 1호|pp.42-44 (3 pages)
- ㆍ 발행정보
- 대한임상독성학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
Metformin which is an oral hypoglycemic agents, acts by enhancing insulin sensitivity, decreasing hepatic glucose production and increasing peripheral utilization of glucose. Deliberate self poisoning with oral hypoglycemic agents is rare. The lactic acidosis associated with metformin toxicity is well described in the medical literature. Metformin overdose even in otherwise healthy patients may produce a profound and life threatening lactic acidosis. We report a case of massive metformin ingestion(75g) in a patient presenting with lactic acidosis and hypotension. She died 24h after presenting to our emergency department despite bicarbonate treatment and hemofiltration therapy.