Natural element method (NEM) is quick in research activities by natural sciences and mechanical engineering fields, and from which good results are watched by various engineering fields and applied too. However no paper or research about the applied case has announced yet. Therefore on this paper, I will rediscover an optimum design and apply NEM into other fields with NEM for existing optimum design of mainly using FEM. NEM and genetic algorithm (GA) are applied to optimize a membrane with a center hole. The optimal design obtained by NEM is compared to the counterpart obtained by the finite element method (FEM). Result by NEM is found to be better than the result by FEM. NEM can be a feasible analysis tool in design optimization.