This paper investigates the effects of outdoor pressure fluctuations on natural ventilation through an opening on a building envelope. The ventilation airflow rate depends on the magnitude and the period of the pressure fluctuations, the size of the opening relative to the space volume, and the resistance characteristics of the opening. Non-dimensional parameters have been derived, which determine indoor pressure responses due to outdoor pressure fluctuations. The flow regions are categorized into (1) synchronized region, (2) opening resistance region, and (3) transition region depending on the non-dimensional parameter derived. Pressure fluctuations and flow characteristics are investigated numerically using the 4th order Runge-Kutta method.