Objectives: To identify the willingness of laypersons to perform the cardiopulmonary resuscitation(CPR), we analyzed their characteristics of socio-economic status and health-medical conditions associated with their willingness. Methods: Based on a health survey of Incheon Metropolitan City adults(N=5,114), tests of the differences between a group with willingness to perform CPR(=1,531) and a group with non-willingness to perform CPR(=3,583), and a logistic regression analysis of two groups were executed on socio-economic status-gender, age, marital stats, education level, jobs, and monthly household income-and health-medical conditions-CPR-related self-confidence, CPR education, chronic diseases, accident experience, EMS(emergency medical service) experience, and health status. Results: The rate of the willingness group was 29.9%, which was relatively lower than other developed countries. There were statistically significant differences between the willingness group with the non-willingness group on gender, age, jobs, CPR-related self-confidence, CPR education, and so on. Furthermore, Gender, age, students or armed forces among jobs, CPR-related self-confidence, and CPR education were statistically significant influential factors on the willingness to perform CPR. Conclusion: This study indicated that there was considerable variation in socio-economic status and health-medical conditions associated with willingness to perform CPR in Incheon. The CPR education aimed at increasing CPR-related self-confidence and correcting inaccurate perceptions of CPR attitudes would promote its use in response to out-of-hospital cardiac arrest.