Recent a few decades, the microtechnology has been progressed so rapidly and applied in diverse areas. Especially, this technology was focused on the field of biotechnology and medicine because of its size and simple fabrication process. In this paper, the current status of microtechnology is briefly introduced from the aspect of material, process and device and the application of this technology in biotechnology and medicine is also described. The microtechnology will be more broadly applied in future in the biotechnology and medicine area and the biomedical engineer should have continuous interests in this technology.