In this study, seismic response control performance of decentralized response-dependent MR damper which generates the control force using only the response of damper-installed floor, was experimentally investigated through the tests of a full-scale structure installed with large MR dampers. The performance of the decentralized control algorithm was compared to those of the centralized ones such as Lyapunov, modulated homogeneous friction, and clipped-optimal control. Hybrid mass damper were controlled to induce seismic response of the full-scale structure under El Centro earthquake. Experimental results indicated that the proposed decentralized MR damper provided superior or equivalent performance to centralized one in spite of using damper-installed floor response for calculating input voltage to MR damper.