To obtain the data of the pressure loss and differential pressure at the inside of the stack that was composed of 126 cells with 7,500 cm2 electrode area, 75kW molten carbonate fuel cell system has been operated. Computational fluid dynamics was applied to estimate reactions and thermal fluid behavior inside of the stack that was adopted with internal manifold type separator. The pressure loss coefficient K showed 72.29 to 84.01 in anode and 6.34 to 8.75 in cathode at low part of cells at the inside of 75 kW MCFC stack respectively. Meanwhile, the pressure loss coefficient of the higher part of cells at the interior of the stack showed 15.36 and 56.44 in anode and cathode respectively. These results mean that there is no big total pressure difference between anode and cathode at the inner part of 75 kW MCFC stack. This result will be reflected in 250kW MCFC system design.