Several ginsenoside ($R_{b1},;R_{b2},;R_c,;R_d,;R_e,;R_f,;R_{g1};and;R_{g3}$) are neuroprotective and antinociceptive agents. In this study, we assessed the effects of these ginsenosides following intracerebroventricular (i.c.v) administration on the nociceptive behaviors induced by intrathecal injection of pro-inflammatory cytokines (tumor necrosis factor-a $(TNF-{alpha})$, interleukin-$1{eta};(IL-1{eta})$, and interferon-${gamma} ;(IFN-{gamma})$). The ginsenosides, $R_{b1},;R_{b2},;R_c,;R_d,;R_e,;R_f,;R_{g1};and;R_{g3}$ significantly attenuated the nociceptive behavior induced by $TNF-{alpha}$, $(IL-1{eta})$, and $IFN-{gamma}$ injection, but ginsenoside- $R_{g3}$ did not. These results suggest that several ginsenosides may regulate the nociceptive processing induced by pro-inflammatory cytokines.