A series of chroman-2-carboxylic acid N-(substituted)phenylamides (2a-s, 3a-j) were synthesized. Their ability to inhibit nuclear $factor-{kappa}B$ ($NF-{kappa}B$) activity was evaluated in lipopolysaccharide (LPS)-stimulated macrophage RAW 264.7 cells and their antioxidant activity was examined. $NF-{kappa}B$ inhibition by chroman compounds was not related to their antioxidant activity. Compounds with -H,$-NO_2$ monosubstituents and $-OCH_3,;-CF_3$ disubstituents on the phenyl ring were poor inhibitors of $NF-{kappa}B$ activity. Compounds with $-CH_3,;-CF_3,;-CI$ monosubstituents or -CI, $-CH_3$ disubstituents exhibited moderate to good $NF-{kappa}B$ activity inhibition $(IC_{50}:;18.2-95.8;{mu}M)$. The most active $NF-{kappa}B$ inhibitor, 2s, contained a 4-CI $(IC_{50}:;18.2;{mu}M)$ substituent on the phenyl ring and was slightly more potent than the compound KL-1156 (1) $(IC_{50}:;43.9;{mu}M)$.