This study carried out the safety evaluation of non-refillable butane can for portable gas range equipped with relief valve for prevention of explosion. The can is heated by electric heater at the real using condition and the extreme condition after installing at a portable gas range for checking the operating pressure and the evaluating suitability of releasing flux. And the possibility of fire or explosion was tested when the gas was released from the relief valve at the real condition. As a result of this safety evaluation test, a non-refillable butane can with relief valve prevents the can from exploding by control of internal pressure.