In this paper, we propose a method for optimizing a multiple pronunciation dictionary used for modeling pronunciation variations of non-native speech. The proposed method removes some confusable pronunciation variants in the dictionary, resulting in a reduced dictionary size and less decoding time for automatic speech recognition (ASR). To this end, a confusability measure is first defined based on the Levenshtein distance between two different pronunciation variants. Then, the number of phonemes for each pronunciation variant is incorporated into the confusability measure to compensate for ASR errors due to words of a shorter length. We investigate the effect of the proposed method on ASR performance, where Korean is selected as the target language and Korean utterances spoken by Chinese native speakers are considered as non-native speech. It is shown from the experiments that an ASR system using the multiple pronunciation dictionary optimized by the proposed method can provide a relative average word error rate reduction of 6.25%, with 11.67% less ASR decoding time, as compared with that using a multiple pronunciation dictionary without the optimization.