The RS-232C (Unbalanced serial) and RS-485 (balanced serial) are standard in serial communication. RS-485 uses a differential electrical signal, as opposed to unbalanced signals referenced to ground with the RS-232. Differential transmission, which uses two lines each for transmit and receive signal results in greater noise immunity and longer distances as compared to the RS-232C. The greater noise immunity and distance are big advantages in industrial environments. In general, one protocol on one serial interface is very normal application. In this study, we implemented multi protocols on one serial RS-485 interface and examine the performance and result with hanging multi equipments.