In this paper, we propose a voice instruction-based takeoff system for aircraft including unmanned aerial vehicle (UAV). The system consists of voice recognition (VR), flight state checking and instruction (command) execution. Employing VR technology, the proposed takeoff system can provide simplified and more reliable takeoff procedures to pilots. By virtue of the VR-based system it is expected that human errors during takeoff phase can be reduced and further navigation safety can be improved.