Purpose: The purpose of this study was to identify the relationship among self-efficacy, depression, life satisfaction and death attitude of college students. Methods: The subjects consisted of 232 college students. Data were collected by self-reported questionnaires, which were constructed to include self-efficacy, depression, satisfaction with life, and death attitude. Data were analyzed by the SPSS/PC WIN. 12.0 program. Results: Death attitude and life satisfaction of college students were significantly different according to frequency of death ideation. Death attitude for college students correlated with self-efficacy, depression, and life satisfaction. The most significant predictor of death attitude for college students was life satisfaction. Conclusion: The above findings indicate that death attitude for college students is influenced by self-efficacy, depression, and life satisfaction. These findings suggest that a death education program to improve life satisfaction and to give a positive attitude toward death is needed for college students.