For most bearings, it is a common requirement to have long durability. Especially wheel bearing fatigue life is the most important in automotive quality. The contact fatigue life analysis of automotive wheel bearing considering real raceway rough surface is presented in this paper. Contact stresses are obtained by contact analysis of a semi-infinite solid based on the use of influence functions; the subsurface stress field is obtained using rectangular patch solutions. Mesoscopic multiaxial fatigue criterion which can yield satisfactory results for non-proportional loading is then applied to predict fatigue damage. Suitable counting method and damage rule were used to calculate the fatigue life of random loading caused by rough surface. The life analysis considering real rough surface of wheel bearing raceway is in good agreement with the experimental results.