This paper presents an integrated optimal design technique of a hybrid structure-damper system for improving the seismic performance of the structure. The proposed technique corresponds to the optimal distribution of the stiffness and dampers. The multi-objective optimization technique is introduced to deal with the optimal design problem of the hybrid system, which is reformulated into the multi-objective optimization problem with a constraint of target reliability in an efficient manner. An illustrative example shows that the proposed technique can provide a set of Pareto optimal solutions embracing the solutions obtained by the conventional sequential design method and single-objective optimization method based on weighted summation scheme. Based on the stiffness and damping capacities, three representative designs are selected among the Pareto optimal solutions and their seismic performances are investigated through the parametric studies on the dynamic characteristics of the seismic events. The comparative results demonstrate that the proposed approach can be efficiently applied to the optimal design problem for improving the seismic performance of the structure.