A number of construction practices, implemented during the design process of a reinforced concrete (RC) structural system, may have significant consequences on the behaviour of the structural system in the case of earthquake loading. Although a number of provisions are imposed by the contemporary Greek national design codes for the seismic design of RC structures, in order to reduce the consequences, the influence of the construction practices on the seismic behaviour of the structural system remains significant. The objective of this work is to perform a comparative study in order to examine the influence of three, often encountered, construction practices namely weak ground storey, short and floating columns and two combinations on the seismic performance of the structural system with respect to the structural capacity and the maximum interstorey drifts in three earthquake hazard levels.