In this paper, optimum methods of wind-induced vibration control of high-rise buildings are mainly studied. Two optimum methods, genetic algorithms (GA) method and Rayleigh damping method, are firstly employed and proposed to perform optimum study on wind-induced vibration control, six target functions are presented in GA method based on spectrum analysis. Structural optimum analysis programs are developed based on Matlab software to calculate wind-induced structural responses. A high-rise steel building with 20-storey is adopted and 22 kinds of control plans are employed to perform comparison analysis to validate the feasibility and validity of the optimum methods considered. The results show that the distributions of damping coefficients along structural height for mass proportional damping (MPD) systems and stiffness proportional damping (SPD) systems are entirely opposite. Damping systems of MPD and GAMPD (genetic algorithms and mass proportional damping) have the best performance of reducing structural wind-induced vibration response and are superior to other damping systems. Standard deviations of structural responses are influenced greatly by different target functions and the influence is increasing slightly when higher modes are considered, as shown fully in section 5. Therefore, the influence of higher modes should be considered when strict requirement of wind-induced vibration comfort is needed for some special structures.