Objectives : Dong-si acupuncture therapy is being widely used because of good clinical result. The purpose of this study was to compare the location and efficacy of Dong-si acupoints and 14 meridian acupoints. Conclusions : 1. Dong-si acupoints on the lower extremity total 83. Among them, 16 acupoints are the same as 14 meridian acupoints. 2. Between the same location points, the efficacy of each Dong-si acupoints is similar to that of each of the 14 meridian acupoints in cases of musculoskeletal pain diseases, paralytic diseases, urogenital diseases, and gastrointestinal diseases. 3. Dr. Dong studied deeply into the 14 meridian acupoints and created Dong-si acupuncture therapy. He said that the distribution of acupuncture points was closely related to the 14 meridians. 4. I think that we are able to apply Dong-si acupuncture therapy to clinical use widely by comprehending the character of the 14 meridian acupoints and each meridians.