Objectives : The aim of this study was to understand electro-physiological peculiarity in meridian and acupoints, and understand acupuncture therapy mechanism as an electro-physiological viewpoints. Methods : I reviewed the articles on the electro-physiological peculiarity of the meridian and acupoints Results and Conclusions : It has been reported that meridian and acupoints have high-electrical conductivity and row-electrical resistance. On this scientific basis, to understand the mechanism of acupuncture therapy, I made some hypotheses. At first, there is electro-property in meridian and acupoint. The second, energy flowing in meridian is related with electro-property. The third, there is electronic interaction between practitioner of acupuncture therapy and patient receiving acupuncture therapy. The forth, acupuncture effects which may be expressed by the electro-charge capacity is transfered between practitioner and patient via acupuncture. Electro-charge induced via acupuncture in practitioner may be an important factor that initiate the electro-charge changes in meridian and acupoint of patient.