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인삼(人蔘)이 자궁근종(子宮筋腫)의 세포주기(細胞週期)와 세포자멸사(細胞自滅死)에 미치는 영향(影響)
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  • 인삼(人蔘)이 자궁근종(子宮筋腫)의 세포주기(細胞週期)와 세포자멸사(細胞自滅死)에 미치는 영향(影響)
  • Effects of Ginseng Radix Alba on Cell Cycle and Apoptosis of Human Uterine Myoma Cells
저자명
최재호,이진무,이창훈,조정훈,장준복,이경섭,Choi. Jae-Ho,Lee. Jin-Moo,Lee. Chang-Hoon,Cho. Jung-Hoon,Jang. Jun-Bock,Lee. Kyung-Sub
간행물명
大韓漢方婦人科學會誌
권/호정보
2008년|21권 2호|pp.27-37 (11 pages)
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대한한방부인과학회
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Purpose: This study was conducted to investigate the effects of Ginseng Radix Alba extract solution on the cell cycle regulation, apoptosis of human uterine myoma cells. Methods: Primary cultured human uterine myoma cells were treated with extract solution of Ginseng Radix Alba concentration of 1, 10 and $100mg/m{ell}$ for 48 hours. We underwent flow cytometry and western blotting for cell cycle and apoptosis related factors. Results: In flow cytometry, a slight promotion of G1 phase in $1mg/m{ell}$ group had been observed but, simultaneously a delay of G1 phase in 10 and $100mg/m{ell}$ groups were also observed. The manifestation of cyclin D1 in Ginseng Radix Alba extract solution medicated group increased compared to the control group. The manifestation of Bax controlling apoptosis increased in terms of concentration but Bcl-2 showed no change. Also VEGF increased in terms of concentration. Conclusion: The present study suggests that Ginseng Radix Alba extract solution treatment in human uterine myoma cells induce the delay of cell cycle and apoptosis. These results suggest that Ginseng Radix Alba will be a promising agent for use in therapeutics agents against human uterine myoma.