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청증보폐탕(淸蒸補肺湯)의 면역조절능(免疫調節能)을 통한 항천식(抗喘息) 효능(效能)
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  • 청증보폐탕(淸蒸補肺湯)의 면역조절능(免疫調節能)을 통한 항천식(抗喘息) 효능(效能)
저자명
박종광,최학주,김선빈,김동희,Park. Jong-Kwang,Choi. Hak-Joo,Gim. Seon-Bin,Kim. Dong-Hee
간행물명
論文集 : 大田大學校 韓醫學硏究所. 韓醫學編
권/호정보
2008년|17권 2호|pp.69-86 (18 pages)
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대전대학교 한의학연구소
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

In order to validate the objective efficacy of CBPT on anti-asthma and to develop effective therapeutics for asthma treatments, immunological modulatory mechanism was studied using animal model using OVA-Alum. The results are listed below. When treated with CBPT, survival rate of hFCs at 250 ug/ml was above 90%. AST and ALT, indicators of liver function measurements were in the normal range. Compared to the control group, CBPT treated group showed significant reduction in liver weights at both 400 and 200 mg/kg, and significant decrease of total liver cells at 400 mg/kg. Significant increase in CD4+ and CD8+ cells in DLN was observed in the CBPT treated group. Slight increase in CD3+, CD4+/CD25+ cells were also observed. On the other hand, CBPT significantly reduced the CD3+/CD69+ cell numbers at both concentrations. Slight decrease of CD19+ cells was also observed. CBPT significantly reduced the CD3e+/CD69+, CCR3+ and CD11b+/Gr-1+ cells in lung tissues at both doses. However, significant decrease of CD3e+ and B220+/IgE+ cells was only observed at 400 mg/kg dosed group. The results above strongly suggest the anti-asthmatic effect of CBPT through immunological modulation. By using various concentrations of CBPT, broader clinical applications of CBPT on anti-asthmatic treatment can be developed. The EBM database should provide valuable information in the development of drugs for asthma treatments.