Purpose: The purpose of this study was to examine the effects of aroma-inhalation on depression, sleep, mood, and smell in stroke patients and their caregivers. Method: This study employed one group pretest-posttest repeated design. Data were collected at three time points: baseline(pre-test), 10 days and 20 days after the intervention(Post-test1 and post-test2, respectively). The sample included a total of 23 subjects. Data were analyzed by SPSS 12.0 program using repeated measure ANOVA. Results: Depression was not statistically significant difference among pre-test, post-test1 and post-test2. Sleep was improved after intervention $37.61{pm}7.41$(pre-test), $41.22{pm}8.26$ (post-test1), $44.33{pm}7.67$(post-test2) (F=8.182. p=.001) Mood was significantly improved after intervention: $16.95{pm}4.89$(pre-test), $14.89{pm}6.31$(post-test1), $12.11{pm}5.04$(post-test2). Smell including smell perception, discomfort due to smell and relation between age and smell was significantly improved after intervention: $2.63{pm}1.20$ (pre-test). $2.00{pm}1.16$(post-test1), $1.63{pm}.96$(post-test2) (F=6.176. p=.006) in smell perception, $2.50{pm}1.10$ (pre-test). $1.81{pm}.91$(post-test1), $1.19{pm}.40$(post-test2) (F=12.26. p=.000) in discomfort due to smell and $3.53{pm}1.18$(pre-test). $2.59{pm}1.46$(post-test1), $2.53{pm}1.33$(post-test2) (F=4.148, p=.025) in relation between age and smell. Conclusion: The results suggest that aroma-inhalation may have an effect on sleep, mood and smell and can be effective nursing intervention to increase the relaxation in stroke patients and their caregivers.