In the blind Maximum-likelihood (ML) detection for Orthogonal Space-Time Block Codes (OSTBC), the problem of ambiguity in determining the symbols has been a great concern. A possible solution to this problem is to apply semi-blind ML detection, i.e. the blind ML decoding with pilot symbols or training sequence. In order to increase the performance, the number of pilot symbols or length of training sequence should be increased. Unfortunately, this leads to a significantly decrease in system spectral efficiency. This work presents an approach to resolve the aforementioned issue by introducing a new method for constructing transmitted information symbols, in which transmitting information symbols drawn form different modulation constellations. Therefore, the ambiguity can be easily eliminated. In addition, computer simulation is implemented to verify the performance of the proposed approach.