The effects of Asiasarum Root on the cell mediated and humoral immune responses were investigated in ICR mice. ICR mice received intraperitoneal injection of methanol extracts (ether fraction, butanol fraction, water fraction) for 5 days before sensitization. The change of body weight (%), the organ weight ratio (%), the numbers of RBC and WBC, the ear swelling by dinitrofluorobenzene, the titers of hemagglutination (HA) and hemolysin (HY) to SRBC were determined. The results were as follows; 1. The change of body weight (%) showed a tendency of increasing. 2. The weight of spleen (%) decreased. 3. Ear swelling was maximum at 48 hours after challenge and was significantly decreased in the groups. 4. The numbers of RBC and WBC were decreased. 5. HA and HY titers were decreased.