A numerical analysis of three dimensional incompressible turbulent flows through high pressure drop control valves was carried out by using a CFD-ACE code to develop anti-cavitation control valve used in LNG marine system. For this, numerical simulation was performed on several models of control valve that have different orifice diameters of anti-trim and the size of valve discharge. In this study, flow characteristics of control valves with complex flow fields including pressure drop, cavitation effect and variation of flow coefficient as well as correlation of discharge coefficient were investigated and analyzed. Comparing with conventional control valves, newly designed valves by using the CFD analysis showed an improved flow pattern with reduced cavitation and an anticipated performance characteristic.