The Dual Unit Optimizer 2000 MWe (DUO2000) is put forward as a new design concept for large power nuclear plants to cope with economic and safety challenges facing the $21^{st}$ century green and sustainable energy industry. DUO2000 is home to two nuclear steam supply systems (NSSSs) of the Optimized Power Reactor 1000 MWe (OPR1000)-like pressurized water reactor (PWR) in single containment so as to double the capacity of the plant. The idea behind DUO may as well be extended to combining any number of NSSSs of PWRs or pressurized heavy water reactors (PHWRs), or even boiling water reactors (BWRs). Once proven in water reactors, the technology may even be expanded to gas cooled, liquid metal cooled, and molten salt cooled reactors. With its in-vessel retention external reactor vessel cooling (IVR-ERVC) as severe accident management strategy, DUO can not only put the single most querulous PWR safety issue to an end, but also pave the way to very promising large power capacity while dispensing with the huge redesigning cost for Generation III+ nuclear systems. Five prototypes are presented for the DUO2000, and their respective advantages and drawbacks are considered. The strengths include, but are not necessarily limited to, reducing the cost of construction by decreasing the number of containment buildings from two to one, minimizing the cost of NSSS and control systems by sharing between the dual units, and lessening the maintenance cost by uniting the NSSS, just to name the few. The latent threats are discussed as well.