The fatigue crack growth behavior of high strength X80 pipeline steel was investigated with compact tension specimens that crack growth directions were aligned either parallel or normal to the rolling direction of the pipeline. Also, the fatigue crack growth rates for welded joint of X80 pipeline steel were investigated with compact tension specimens that crack growth directions were aligned either parallel or normal to the welding line. The experimental results indicated the fatigue crack growth behavior was markedly different in three zones, weld metal, heat affected zone and base metal of welded joints. There was a trend toward increment in the fatigue life of weld metal and heat affected zone as compared with the X80 pipeline steel.