Ferritic stainless steel, which has been used as material for decoration parts in automobile, is recently used as material for the exhaust system due to its good performance at high temperature. To improve the fuel efficiency and purify automotive exhaust gas, it is needed to increase the temperature of exhaust gas. However, it is frequently reported that the rising of the temperature of exhaust gas increases thermal stress at exhaust manifold, which results in thermal fatigue failure in welded joints. Therefore, in this study, effects of chemical composition of steel and welding parameters on thermal fatigue properties of synthetic heat affected zone in ferritic stainless steel have been investigated. It has been found that thermal fatigue life in heat affected zone is affected by bead shape of welded joint and amount of soluble Nb in steel. Especially, Nb-Ti added steel has higher thermal fatigue life in comparison to Nb added steel, which is attributed to difference of precipitation behavior in both steels.