We propose optimization method of two-inductor loaded small loop antennas using simple genetic algorithm. To optimize the loop antennas for the RFID and the mobile phone band, we changed positions and values of the two inductors in the loop antenna. Visual basic was used to make genetic algorithm and to calculate fitness values by controlling the commercial EM software. The bandwidth of the optimized RFID loop antenna is 10 MHz at the center frequency of 922 MHz and that of the mobile phone antenna are 84 MHz and 266 MHz at the center frequency of 948 MHz(GSM band) and 1.81 GHz(DCS band), respectively.