Interzonal air movements are important to characterize overall ventilation performance of complicated multi-zone buildings. Tracer gas techniques are widely used to measure ventilation rates, ventilation effectiveness, and interzonal air movements. Depending on the number of gases used, they are divided into single and multi tracer gas methods. This paper deals with the comparison of the tracer gas methods in measuring air exchange rate between rooms. Experiments have been conducted in a simple two-room model with known airflow rates. In multi-gas procedure, the concentration decays of two tracer gases, i.e SF6 and R134a are measured after simultaneous injections in each room. The single tracer gas method is also applied by injecting SF6 gas with a time lag between two rooms. The data reduction procedures are developed to obtain the interzonal airflow rate using the matrix inversion, and various data manipulation methods are tested, such as data shift, interpolation, and smoothing. Uncertainty for each airflow rate is investigated depending on the parameters based on the setting values.