Purpose: This study aimed to investigate the prevalence of depression and to identify the influencing factors of depression. Methods: The data of the 2006 Youth Health Risk Behavior web-based Survey Collected by the Korea Center Disease Control was analyzed by Chi-square test, logistic regression using the SPSS program. Results: The influencing factors of depression by general characteristics were gender, school, health status, socioeconomic status and living with both parents. The influencing factors of depression by health risk behaviors were perceived stress, sleep, effort for weight loss, smoking, drinking and drug use. Conclusion: This study suggested that Depression prevention programs should be developed in considering preventing and reducing health risk behaviors.