To improve the effectiveness and economics the bridge design methodology considering the bridge/rail longitudinal analysis and bridge/vehicle dynamic effect suggested in this study. The reliability-based Life-Cycle Costs(LCC) effective optimum design is applied to a 2-main steel girder bridge, 5$ imes$(1@50m) for comparison with conventional design, initial cost optimization and equivalent LCC optimization. As a result of the optimum design based on reliability, it may be stated that the design of High-Speed railway bridges considering the bridge/rail longitudinal analysis and bridge/vehicle dynamic effect are more efficient than typical existing bridges and LCC optimization without respect to bridge/rail longitudinal analysis and bridge/vehicle dynamic effect. The result of optimization design considering the interaction, design methodology suggested in this study, is higher than result of initial cost optimization design in initial cost, but that has the advantage than result of initial cost optimization design in expected LCC.