Natural smoke ventilator is one of domestic prescriptive methods to be used to exhaust smoke in case of fire in a high-rise buildings. The goal of this study is to evaluate the stack effect and the smoke exhaust performance in high-rise buildings with the opening of natural smoke ventilators using computer modeling technology, thus to estimate its effectiveness as a tool of smoke exhaust. For this purpose, the pressure differential in a domestic high-rise building with natural smoke ventilators was experimentally measured to analyze the stack effect with the closure or the opening of natural smoke ventilators and to calculate compensated air leakage of the building. Computer modeling based on experimentally measured data was carried out to estimate effectiveness of natural smoke ventilators in high-rise buildings using CONTAMW network program.