When we assign frequency resources to a new radio service, the existing services need not to be interfered with by the new service. Therefore, when we make a frequency assignment, a guard band is necessary to separate adjacent frequency bands so that both can transmit simultaneously without interfering with each other. In this paper, we propose an efficient frequency guard band decision rule for avoiding interference between radio services. The guard band is established based on the probability of interference in the previously arranged scenario. The interference probability is calculated using the spectrum engineering advanced Monte Carlo(MC) analysis tool(SEAMCAT). After applying the proposed algorithm to set up the frequency guard band, we can decide on the guard band appropriately because the result satisfies the predefined criterion.