This study investigated the relationships between stress-coping strategies and the mental health of college students from health related and non-health related departments by developing an efficient managerial indicator using student lifestyle guidance and employment guidance. Results indicated that there are differences in stress factors between general characteristics and departments. Hope management was used the most for stress-coping strategies for health related departmental students and emotional management was used the most for stress-coping strategies for non-health related departmental students. Compulsion scored high for health related departmental students in regards to mental health while fear and hostility scored high for non-health related departmental students. Results also showed that active stress-coping strategies and paranoia were negatively correlated, while passive stress-coping strategies and many mental health substructure were positively correlated. In conclusion, negative influences on mental health is the reason for instances where stress-coping strategies were not pertinent. Therefore colleges and professors should consider developing a program which can appropriately manage and regulate college students stress and thereby allow students to actively participate with benefits from college lifestyle guidance and employment guidance.