Flow instability in LRE (liquid rocket engine) occurs due to various reasons such as flow interactions with valve, orifice and venturi, etc. The inception of cavitation, especially in the propellant feeding system, is the primary cause of mass and pressure oscillations because of the cyclic formation and depletion of cavitation. Meanwhile, the main propellant in a liquid rocket engine is the cryogenic fluid, which properties are very sensitive to temperature variation. And the change of propellant properties to temperature variation by thermodynamic effect needs to be properly taken into account in the flow analysis in order to understand basic mechanisms for cryogenic cavitation. The present study focuses on the formation of cryogenic cavitation by using the IDM model suggested by Shyy and coworkers. The flow instability was also numerically investigated in the downstream of orifice with a developed numerical code. Calculation results show that cryogenic cavitation can be a primary source of flow instability, leading to mass fluctuations accompanied by pressure oscillations. The prediction of cavitation in cryogenic fluid is of vital importance in designing a feeding system of an LRE.