Mobile wireless networks continue to be plagued by theft of identify and intrusion. Both problems can be addressed in two different ways, either by misuse detection or anomaly-based detection. In this paper, we propose a dissimilarity-based anomaly detection method which can effectively identify abnormal behavior such as mobility patterns of mobile wireless networks. In the proposed algorithm, a normal profile is constructed from normal mobility patterns of mobile nodes in mobile wireless networks. From the constructed normal profile, a dissimilarity is computed by a weighted dissimilarity measure. If the value of the weighted dissimilarity measure is greater than the dissimilarity threshold that is a system parameter, an alert message is occurred. The performance of the proposed method is evaluated through a simulation. From the result of the simulation, we know that the proposed method is superior to the performance of other anomaly detection methods using dissimilarity measures.