This paper presents an experimental study of a newly developed composite floor system, built up from thin-walled C-profiles and upper concrete deck. Trapezoidal sheeting provides the formwork and the fastening of the sheet transmits the shear forces between the C-profiles and the deck. The modified formation of the standard self-drilling screw in the beam-to-sheet connection is applied as shear connector. Push-out tests are completed to study the composite behaviour of the different connection arrangements. On the basis of the test results the behaviour is characterized by the observed failure modes. The design values of the connection stiffness and strength are calculated by the recommendation of Eurocode 4. In the next phase of the experimental study six full-scale composite beams are tested. The global geometry is based on the proposed geometry of the developed floor system. The applied shear connections are selected as the most efficient arrangements obtained from the push-out tests. The experimental behaviour of the composite beams are discussed and evaluated. As a conclusion of the experimental study the Eurocode 4 plastic design method is validated for the developed composite floor.