For long-span suspension bridges with their intrinsic limit in flutter, some counter measures, for example, central stabilizers, should be adopted to improve aerodynamic stability to meet with the appropriate wind resistance requirements. The present paper introduces aerodynamic stabilization for long-span suspension bridges with box girders by using central stabilizers based on Xihoumen Bridge with the main span of 1650 m. The aerodynamic stabilization study covers experimental investigation of sectional model testing, comprehensive evaluation of three central stabilizers and theoretical analysis of stabilizing mechanism related to flutter derivatives, aerodynamic damping and degree participation.