This paper describes the development of modified heat of hydration and maturity-strength models for concrete containing fly ash and slag. The modified models are developed based on laboratory and literature test results, which include different types of cement, fly ash, and slag. The new models consider cement type, water-to-cementitious material ratio (w/cm), mineral admixture, air content, and curing conditions. The results show that the modified models well predict heat evolution and compressive strength development of concrete made with different cementitious materials. Using the newly developed models, the sensitivity analysis was also performed to study the effect of each parameter on the hydration and strength development. The results illustrate that comparing with other parameters studied, w/cm, air content, fly ash, and slag replacement level have more significantly influence on concrete strength at both early and later age.