- 중국, 베트남산 약용식물의 최종당화산물 생성저해활성 검색 (IV)
- ㆍ 저자명
- 김종민,김영숙,김주환,유정림,김진숙,Kim. Jong-Min,Kim. Young-Sook,Kim. Joo-Hwan,Yoo. Jeong-Lim,Kim. Jin-Sook
- ㆍ 간행물명
- 생약학회지
- ㆍ 권/호정보
- 2009년|40권 4호|pp.388-393 (6 pages)
- ㆍ 발행정보
- 한국생약학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
Advanced glycation end products (AGEs) have been implicated in the development of diabetic complications. The AGEs inhibitors or cross-link breakers attenuate various functional and structural manifestations of diabetic complications. In this study, 64 herbal medicines from China and Vietnam have been investigated with an in vitro evaluation system using AGEs inhibitory activity. Of these, eight herbal medicines ($IC_{50}$<50 ${mu}g$/ml) were found to have strong AGEs inhibitory activity compared with aminoguanidine (14 days, $IC_{50}$=75.98 ${mu}g$/ml; 28 days, $IC_{50}$=88.27 ${mu}g$/ml). Particularly, four herbal medicines, Buddleja officinalis (whole plant), Syzygium cuminii (leaf), Eugenia caryophyllate (seed), and Paeonia suffruticosa (root) showed more potent inhibitory activity (approximately 5-6 fold) than the positive control aminoguanidine.