This paper is proposed the hardware structure and signal processing method of the RF-Tag based on heart sound to develop the mobile biomedical information device for the u-healthcare system. The RF-Tag in this study is consisted of a skin temperature sensor, a dynamic microphone for heart sound detection, Bluetooth communication to transmute healthcare data, and pulse period detection algorithm with adaptive gain controller. We experimented to evaluate performance of the RF-Tag in noisy environments. In addition, the RF-Tag has shown the good performance in the results of experiment. If the proposed methods in this study apply to design the u-healthcare device, we will be able to get the exact health data on real time in mobile environments.