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Chemical Composition of Cinnamomum cassia Leaf Oils and Suppression Effect of Cinnamyl Alcohol on Nitric Oxide Synthase
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  • Chemical Composition of Cinnamomum cassia Leaf Oils and Suppression Effect of Cinnamyl Alcohol on Nitric Oxide Synthase
  • Chemical Composition of Cinnamomum cassia Leaf Oils and Suppression Effect of Cinnamyl Alcohol on Nitric Oxide Synthase
저자명
Lee. Hoi-Seon
간행물명
Journal of applied biological chemistry
권/호정보
2009년|52권 5호|pp.480-485 (6 pages)
발행정보
한국응용생명화학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

The inhibitory effects of components derived from Cinnamomum cassia leaf on nitric oxide (NO) production in RAW 264.7 cells and on expression of inducible NO synthase (iNOS) were determined and compared to those of three commercially available components. Spectral analysis characterized the active constituent of this C. cassia extract as cinnamyl alcohol. The inhibitory effects varied with both chemical and concentration used. Cinnamyl alcohol showed inhibitory effects on NO production of 62.5%, 41.8%, and 22.1% at 1.0, 0.5, and $0.1;{mu}g/{mu}L$, respectively. However, little or no inhibitory effect was observed for cedrene, cinnamic acid, copaene, eugenol, and limonene. Suppression effects of cinnamyl alcohol on iNOS expression were revealed by Western blot analysis. As a naturally occurring therapeutic agent, cinnamyl alcohol could be useful for developing new types of NO inhibitors.