Changes on the CIELab values of the dyed materials after the different chemical finishing treatments using artificial neural network (ANN) and linear regression (LR) models have been predicted. The whole structural properties of fabrics and some process data which were from fiber to the finishing parameters were accepted as inputs in these models. The networks having different structures were established, and it was also focus on the parameters which could affect the performance of the established networks. It was determined that we could successfully predict the color differences values occurring on the material after the finishing applications. In addition, we realized that some ANN parameters affected the prediction performance while establishing the models. After training ANN models, the prediction of the color difference values was also tried by linear regression models. Then, extra ANN models were established for all outputs using the parameters as inputs in the LR equations, and the prediction performances of both established models were compared. According to the results, the neural network model gives a more accurate prediction performance than the LR models.