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Enhanced Continuous Production of Lovastatin Using Pellets and Siran Supported Growth of Aspergillus Terreus in an Airlift Reactor
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  • Enhanced Continuous Production of Lovastatin Using Pellets and Siran Supported Growth of Aspergillus Terreus in an Airlift Reactor
  • Enhanced Continuous Production of Lovastatin Using Pellets and Siran Supported Growth of Aspergillus Terreus in an Airlift Reactor
저자명
Gupta. Kamakshi,Mishra. P.K.,Srivastava. Pradeep
간행물명
Biotechnology and bioprocess engineering
권/호정보
2009년|14권 2호|pp.207-212 (6 pages)
발행정보
한국생물공학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Lovastatin, a hypocholesterolemic agent, is a secondary metabolite produced by filamentous microorganism Aspergillus terreus in submerged batch cultivation. Lovastatin production by pellets and immobilized siran cells was investigated in an airlift reactor. The process was carried out by submerged cultivation in continuous mode with the objective of increasing productivity using pellet and siran supported growth of A. terreus. The continuous mode of fermentation improves the rate of lovastatin production. The effect of dilution rate and aeration rate were studied in continuous culture. The optimum dilution rate for pellet was $0.02h^{-1}$ and for siran carrier was $0.025h^{-1}$. Lovastatin productivity using immobilized siran carrier (0.0255 g/L/h) was found to be greater than pellets (0.022 g/L/h). The productivity by both modes of fermentation was found higher than that of batch process which suggests that continuous cultivation is a promising strategy for lovastatin production.