Two chromone glycosides, hyperimone A [7-($eta$-D-glucopyranosyloxy)-5-hydroxy-2-(1-methylethyl)-4H-1-benzopyran-4-one (1)] and hyperimone B [7-($eta$-D-glucopyranosyloxy)-5-hydroxy-3-methyl-4H-1-benzopyran-4-one (2)], together with six known compounds were isolated from the methanolic extract of the whole plant of Hypericum erectum. 1,3,5,6-Tetrahydroxyxanthone (5) and I3, II8-biapigenin (6) showed moderate hepatoprotective activity with $EC_{50}$ values of $160.2;{pm};0.6;{mu}M$ and $217.7;{pm};1.3;{mu}M$, respectively, against tacrine-induced cytotoxicity in HepG2 cells.