The interaction effect of parameters to surface topography and cutting forces is investigated, and the magnitudes of these parameters are determined in the micro-milling of AISI D2 steel. The results show that the feed per tooth has a prominent impact on the surface topography. Due to the low feed per tooth to cutting edge radius ratio, a high surface roughness and a high amount of burrs are obtained in micro-milling. In micro cutting, the cutting forces present are small; in addition, the radial thrust cutting forces are greater than the principal cutting forces. This research proves that the micro-milling process can be applied to the manufacturing of AISI D2 steel micro parts and presents experimental evidence and possible solutions to the cutting parameters.