Multimedia interpretation describes a high level of ion of multimedia content like interrelations and coherencies. In this paper, we describe a multimedia interpretation component from human-centered perspective. In this context, we see the role of the multimedia interpretation component as a liaison between the psychological apparatuses and computer-based artifact. We emphasize this role of multimedia interpretation by outlining a mapping process of the psychological apparatuses and computer-based artifact. This mapping process needs to be transparent to its user so that effective human-centered systems can be achieved. This transparency will provide an immersive environment for the users and enable uninhibited interaction between the users and the artifact. Furthermore, we illustrate how the multimedia interpretation component can be utilized in the medical diagnosis and treatment support application.