To rationally secure and maintain the safety and serviceability of a high-rise building, monitoring of structural responses of members is necessary. As such health monitoring of large-scale building structures has received growing attention by researchers in recent years. However, due to a very large number of members complexity of structural responses of a high-rise building structure, practical difficulties exist in selection of structural members to be sensored for assessment of structural safety of a structure. In this paper, a selection technique for active members for safety monitoring of a high-rise building based on displacement participation factor and strain energy density of a member is investigated.